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Diabetes-related alterations occur in the nucleus of the spermatozoa, and it has also been reported to cause mitochondrial DNA fragmentation, alter metabolism of glucose, glucose transport, and glucose transporters (GLUTs), as well as result in programmed cell death.12 It has been reported that primary exogenous antioxidants in fruits and vegetables, such as vitamins C and E, carotenoids, and phenolics complement the activity of the endogenous antioxidant defense system.7 Clinical studies have shown that a diet rich in fruit, vegetables, whole grains, legumes, and omega-3 fatty acids may prevent the occurrence of cardiovascular diseases, DM, obesity, cancers, and neurodegenerative disorders.13 Other sources of exogenous antioxidants may be dietary supplements such as vitamins, minerals, fibers, fatty acids, or amino acids
